Short-term toxicity of Orange G in pigs.

نویسندگان

  • I F Gaunt
  • I S Kiss
  • P Grasso
  • S D Gangolli
چکیده

Abstract--Orange G was given to groups of three male and three female pigs for 112 days at doses of 0 (control), 2"5, 25 or 250 mg/kg/day. No adverse effects were found in pigs given 2"5 mg Orange G/kg/day. At the higher levels, Heinz bodies were found in the erythrocytes, together with anaemia, reticulocytosis, splenomegaly and, at the highest level only, a histologically demonstrable increase in splenic iron. The no-untoward-effect level in this study was 2.5 mg/kg/day.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Short-term safety and risk evaluation of engine oil enriched by high concentrations copper nanoparticles on the skin

Abstract Objective(s): Copper nano particles are added to ordinary engine oil as an additive to reduce friction and repair damaged surface under friction conditions. However, it is still unclear what environmental effects such a compound might have on conventional engine oils and its toxicity in different animal species has not been determined. The aim of this study is to investigate the ...

متن کامل

Alterations of triglyceride and cholesterol in response to Aloe vera gel extract in HepG2 cells and hyperlipidemic guinea pigs

Aloe vera is well-known for its pharmacological and nutritional properties. The aim of the present study was to determine the effect of A. vera gel extracts on the secretion and cell content of triglyceride (TG) and cholesterol (TC) in HepG2 cells and their short-term effects on the dietary hyperlipidemic guinea pig model. The effects of increasing concentrations of A. vera crude gel and its al...

متن کامل

Attenuating effects of Mangifera indica leaves ethanolic extract against acetamiprid induced reproductive toxicity in male guinea pigs

Acetamiprid (ACP) belonging to the neonicotinoid family used against wide array of pests in agriculture and domestic purposes. In this study, we evaluated the attenuating effects of ethanolic extract of Mangifera indica leaves (EEMI) in averting reproductive toxicity caused by ACP in male guinea pigs. Thirty male guinea pigs were randomly assigned to five treatment groups (n = 6). Grou...

متن کامل

The effects of Curcuma zedoaria and Zingiber zerumbet on non-specific immune responses of grouper Epinephelus coioides

This study was conducted to investigate the effects of Curcuma zedoaria and Zingiber zerumbet on non-specific immune responses of grouper (Epinephelus coioides). Fish were fed an experimental diet containing 0, 0.5, 1.0, 2.5 g/kg of C. zedoaria and Z. zerumbet mixed diets twice daily for two weeks. Non-specific immune parameters such as respiratory burst activity, reactive oxygen species, phago...

متن کامل

The effects of Curcuma zedoaria and Zingiber zerumbet on non-specific immune responses of grouper Epinephelus coioides

This study was conducted to investigate the effects of Curcuma zedoaria and Zingiber zerumbet on non-specific immune responses of grouper (Epinephelus coioides). Fish were fed an experimental diet containing 0, 0.5, 1.0, 2.5 g/kg of C. zedoaria and Z. zerumbet mixed diets twice daily for two weeks. Non-specific immune parameters such as respiratory burst activity, reactive oxygen species, phago...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Food and cosmetics toxicology

دوره 11 3  شماره 

صفحات  -

تاریخ انتشار 1973